Book Chapter

Gene-Environment Interactions in Neurodegenerative Diseases

AJ Hannan

Encyclopedia of Environmental Health | Published : 2011

Abstract

Neurodegenerative disorders affect a large proportion of human populations and many are increasing in their prevalence due to extended life spans and elevated risk of neurodegeneration with age. Recent decades have seen great progress in understanding genetic contributions to neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and motor neuron disease. Transgenic animal models of neurodegenerative disease have allowed gene-environment interactions to be explored, first in HD and then in AD and other neurodegenerative disorders. Research involving transgenic mouse models of HD has shown that environment enrichment dramatically d..

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