Journal article

Free-Water Imaging in White and Gray Matter in Parkinson's Disease

Christina Andica, Koji Kamagata, Taku Hatano, Asami Saito, Wataru Uchida, Takashi Ogawa, Haruka Takeshige-Amano, Andrew Zalesky, Akihiko Wada, Michimasa Suzuki, Akifumi Hagiwara, Ryusuke Irie, Masaaki Hori, Kanako K Kumamaru, Genko Oyama, Yashushi Shimo, Atsushi Umemura, Christos Pantelis, Nobutaka Hattori, Shigeki Aoki

CELLS | MDPI | Published : 2019

Abstract

This study aimed to discriminate between neuroinflammation and neuronal degeneration in the white matter (WM) and gray matter (GM) of patients with Parkinson's disease (PD) using free-water (FW) imaging. Analysis using tract-based spatial statistics (TBSS) of 20 patients with PD and 20 healthy individuals revealed changes in FW imaging indices (i.e., reduced FW-corrected fractional anisotropy (FAT), increased FW-corrected mean, axial, and radial diffusivities (MDT, ADT, and RDT, respectively) and fractional volume of FW (FW) in somewhat more specific WM areas compared with the changes of DTI indices. The region-of-interest (ROI) analysis further supported these findings, whereby those with P..

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Grants

Awarded by JSPS KAKENHI


Awarded by AMED


Awarded by National Health & Medical Research Council (NHMRC)


Awarded by Australian National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

S.A. was supported by Brain/MINDS program from the Japan Agency for Medical Research and Development (AMED); JSPS KAKENHI Grant Number 18H02772 and JP16H06280; and a Grant-in-Aid for Special Research in Subsidies for ordinary expenses of private schools from The Promotion and Mutual Aid Corporation for Private Schools of Japan. K. K. was supported by Brain/MINDS Beyond program from AMED (JP19dm0307024); JSPS KAKENHI (19K17244). C. P. was supported by a National Health & Medical Research Council (NHMRC) Senior Principal Research Fellowship (1105825). A. Z. was supported by the Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowship B (1136649).