Free-water imaging in white and gray matter in Parkinson’s disease

C Andica; K Kamagata; T Hatano; A Saito; W Uchida; T Ogawa; H Takeshige-Amano; A Zalesky; A Wada; M Suzuki; A Hagiwara; R Irie; M Hori; KK Kumamaru; G Oyama; Y Shimo; A Umemura; C Pantelis; N Hattori; S Aoki

Journal article

Free-water imaging in white and gray matter in Parkinson’s disease

C Andica, K Kamagata, T Hatano, A Saito, W Uchida, T Ogawa, H Takeshige-Amano, A Zalesky, A Wada, M Suzuki, A Hagiwara, R Irie, M Hori, KK Kumamaru, G Oyama, Y Shimo, A Umemura, C Pantelis, N Hattori, S Aoki

Cells | MDPI | Published : 2019

DOI: 10.3390/cells8080839

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Abstract

This study aimed to discriminate between neuroinflammation and neuronal degeneration in the white matter (WM) and gray matter (GM) of patients with Parkinson’s disease (PD) using free-water (FW) imaging. Analysis using tract-based spatial statistics (TBSS) of 20 patients with PD and 20 healthy individuals revealed changes in FW imaging indices (i.e., reduced FW-corrected fractional anisotropy (FAT), increased FW-corrected mean, axial, and radial diffusivities (MDT, ADT, and RDT, respectively) and fractional volume of FW (FW) in somewhat more specific WM areas compared with the changes of DTI indices. The region-of-interest (ROI) analysis further supported these findings, whereby those with P..

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University of Melbourne Researchers

Andrew Zalesky Author

Christos Pantelis Author

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

S.A. was supported by Brain/MINDS program from the Japan Agency for Medical Research and Development (AMED); JSPS KAKENHI Grant Number 18H02772 and JP16H06280; and a Grant-in-Aid for Special Research in Subsidies for ordinary expenses of private schools from The Promotion and Mutual Aid Corporation for Private Schools of Japan. K. K. was supported by Brain/MINDS Beyond program from AMED (JP19dm0307024); JSPS KAKENHI (19K17244). C. P. was supported by a National Health & Medical Research Council (NHMRC) Senior Principal Research Fellowship (1105825). A. Z. was supported by the Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowship B (1136649).