Variation of Gut Mucosal Microbiome With Anti-Saccharomyces cerevisiae Antibody Status in Pediatric Crohn Disease
Shivani Kansal, Anthony G Catto-Smith, Karen Boniface, Sarah Thomas, Donald J Cameron, Mark Oliver, George Alex, Carl D Kirkwood, Josef Wagner
Journal of Pediatric Gastroenterology and Nutrition | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
OBJECTIVES: Crohn's Disease (CD) is a chronic relapsing condition possibly caused by a dysbiotic microbiome. About 30-60% of CD patients have antibodies to Saccharomyces cerevisiae (ASCA), but any association with gut microbiota is unexplored. We hypothesized that ASCA positivity would predict a signature microbial status and clinical phenotype. METHODS: Ileocolonic mucosal biopsies were obtained from children with CD (n = 135), and controls without inflammatory bowel disease (n = 45). Comparison was made between ASCA status, microbial diversity and clinical characteristics. RESULTS: ASCA was highly specific but poorly sensitive for the diagnosis of CD. In patients with CD, ASCA positivity w..View full abstract
Awarded by NHMRC CDA Senior Research Fellowship
This study was supported by grants from the Australian National and Medical Research Institute and by the Victoria State Scientific Infrastructure Scheme. Carl Kirkwood was supported by an NHMRC CDA Senior Research Fellowship. (607382).