Journal article

Variation of Gut Mucosal Microbiome With Anti-Saccharomyces cerevisiae Antibody Status in Pediatric Crohn Disease

Shivani Kansal, Anthony G Catto-Smith, Karen Boniface, Sarah Thomas, Donald J Cameron, Mark Oliver, George Alex, Carl D Kirkwood, Josef Wagner

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

OBJECTIVES: Crohn's Disease (CD) is a chronic relapsing condition possibly caused by a dysbiotic microbiome. About 30-60% of CD patients have antibodies to Saccharomyces cerevisiae (ASCA), but any association with gut microbiota is unexplored. We hypothesized that ASCA positivity would predict a signature microbial status and clinical phenotype. METHODS: Ileocolonic mucosal biopsies were obtained from children with CD (n = 135), and controls without inflammatory bowel disease (n = 45). Comparison was made between ASCA status, microbial diversity and clinical characteristics. RESULTS: ASCA was highly specific but poorly sensitive for the diagnosis of CD. In patients with CD, ASCA positivity w..

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