Journal article

Associations of Body Composition Trajectories with Bone Mineral Density, Muscle Function, Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project

David Scott, Markus J Seibel, Robert Cumming, Vasi Naganathan, Fiona Blyth, David G Le Couteur, David J Handelsman, Benjumin Hsu, Louise M Waite, Vasant Hirani

The Journals of Gerontology: Series A | OXFORD UNIV PRESS INC | Published : 2020


BACKGROUND: Weight loss increases fracture risk in older adults. We aimed to determine associations of 2-year body composition trajectories with subsequent falls and fractures in older men. METHODS: We measured appendicular lean mass (ALM) and total fat mass (FM) by dual-energy X-ray absorptiometry at baseline and Year 2 in 1,326 community-dwelling men aged ≥70 and older. Body composition trajectories were determined from residuals of a linear regression of change in ALM on change in FM (higher values indicate maintenance of ALM over FM), and a categorical variable for change in ALM and FM (did not lose [≥-5% change] versus lost [<-5% change]). Bone mineral density (BMD), hand grip strength,..

View full abstract

University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHRMC Career Development Fellowship

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC; project grant number 301916) and the Ageing and Alzheimer's Institute D.S. is supported by a NHRMC Career Development Fellowship (GNT1123014)