Journal article
Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: A novel therapeutic target?
M Garg, SG Royce, C Tikellis, C Shallue, D Batu, E Velkoska, LM Burrell, SK Patel, L Beswick, A Jackson, K Britto, M Lukies, P Sluka, H Wardan, Y Hirokawa, CW Tan, M Faux, AW Burgess, P Hosking, S Monagle Show all
Gut | BMJ PUBLISHING GROUP | Published : 2020
Abstract
Objective We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. Design Cultured human colonic myofibroblast proliferation and collagen secretion were assessed following treatment with angiotensin (Ang) II and Ang (1-7), their receptor antagonists candesartan and A779, and the ACE inhibitor captopril. Circulating and intestinal RAS components were evaluated in patients with and without IBD. Disease outcomes in patients with IBD treated with ACE inhibitors and angiotensin receptor blockers (ARBs) were assessed in retrospective studies. Results Human colonic myofibroblast proliferation was reduced by Ang (1-7) in a dose-dependent manner (p<0.0..
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Funding Acknowledgements
This work was supported by the Gastroenterological Society of Australia Scholarship awarded to MG and a Broad Medical Research Program Grant awarded to JL.