Journal article

Molecular pathways disrupted by gestational diabetes mellitus

Caitlyn Nguyen-Ngo, Nanthini Jayabalan, Carlos Salomon, Martha Lappas



Gestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for mother and baby. An effective therapeutic that can reduce the incidence of GDM and improve long-term maternal and fetal outcomes is a major research priority, crucially important for public health. A lack of knowledge about the underlying pathophysiology of GDM has hampered the development of such therapeutics. What we do know, however, is that maternal insulin resistance, low-grade inflammation and endothelial cell dysfunction are three central features of pregnancies complicated by GDM. Indeed, data generated over the past decade have implicated a number of candidate regulators of insulin resistanc..

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Awarded by NHMRC

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)

Funding Acknowledgements

Associate Professor Martha Lappas is supported by a Research Fellowship from the Department of Obstetrics and Gynaecology (University of Melbourne) and a Faculty Fellowship from the University of Melbourne. Caitlyn Nguyen-Ngo is supported by an Australian Government Research Training Program (RTP) Scholarship. Nanthini Jayabalan is supported by Scholarship of Public Service Department of Malaysia (JPA). The work from M Lappas's laboratory was funded by project grants from NHMRC (grant no. 454310), Norman Beischer Medical Research Foundation, Diabetes Australia, Melbourne Research Grant Scheme (MRGS), ANZ Charitable Trust (Medical Research and Technology Grant), and Mercy Research Foundation. Dr Carlos Salomon is supported by Lions Medical Research Foundation, National Health and Medical Research Council (NHMRC; 1114013), Diabetes Australia, and Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT 1170809).