Journal article
Does Sex Modify the Effect of Endovascular Treatment for Ischemic Stroke?: A Subgroup Analysis of 7 Randomized Trials
V Chalos, IR De Ridder, HF Lingsma, S Brown, RJ Van Oostenbrugge, M Goyal, BCV Campbell, KW Muir, F Guillemin, S Bracard, P White, A Dávalos, TG Jovin, MD Hill, PJ Mitchell, AM Demchuk, JL Saver, WH Van Zwam, DWJ Dippel
Stroke | Published : 2019
Open access
Abstract
Background and Purpose - Previous studies have reported less favorable outcome and less effect of endovascular treatment (EVT) after ischemic stroke in women than in men. Our aim was to study the influence of sex on outcome and on the effect of EVT for ischemic stroke in recent randomized trials on EVT. Methods - We used data from 7 randomized controlled trials on EVT within the HERMES collaboration. The primary outcome was 90-day functional outcome (modified Rankin Scale). We compared baseline characteristics and outcomes between men and women. With ordinal logistic regression, we evaluated the association between EVT and 90-day functional outcome for men and women separately, adjusted for ..
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Funding Acknowledgements
The University of Calgary received an unrestricted grant from Medtronic for the HERMES collaboration (Highly Effective Reperfusion Using Multiple Endovascular Devices) initiative, which had no role in the study design, data collection, data analysis or interpretation, writing of the report, or the decision to submit the paper for publication. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.