Journal article

Adhesion and Self-Assembly of Lubricin (PRG4) Brush Layers on Different Substrate Surfaces

Mingyu Han, Saimon M Silva, Weiwei Lei, Anita Quigley, Robert MI Kapsa, Simon E Moulton, George W Greene



Lubricin (LUB, aka PRG4), a mucin-like glycoprotein, is best known for the significant role it plays in the boundary lubrication, wear protection, and adhesion control systems in human joints. However, LUB exhibits a number of diverse and useful properties, including a remarkable ability to self-assemble into a telechelic brush structure onto virtually any substrate. This self-assembly behavior has spawned the emergence of numerous nontraditional applications of LUB coatings in numerous areas such as microfluidics, electrochemical sensors, contact lenses, antifouling surfaces, and bionic neural interfaces. Although LUB will readily self-assemble on most substrates, it has become apparent tha..

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Awarded by Australian Research Council

Funding Acknowledgements

Financial support for this project was provided by the Australian Research Council through a Discovery Project award (DP180102287). The authors thank Lubris BioPharma for supporting this research through a gift of recombinant LUB materials. Some of the substrate fabrication for this study was performed in part at the Melbourne Centre for Nano fabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF). The authors acknowledge Dr. Ludovic Dumee (Deakin University) and Dr. Andrea Merenda (Deakin University) for their assistance with the preparation of sputter-coated surfaces. G.W.G. acknowledges Jacob N. Israleachvili for many years of supervision, mentorship, guidance, and friendship. The knowledge and wisdom he has conveyed has helped G.W.G. and many others in science, research, and life.