Journal article

Susceptibility of frogs to chytridiomycosis correlates with increased levels of immunomodulatory serotonin in the skin

Sieara C Claytor, Joel PA Gummer, Laura F Grogan, Lee F Skerratt, Rebecca J Webb, Laura A Brannelly, Lee Berger, Alexandra A Roberts

CELLULAR MICROBIOLOGY | WILEY | Published : 2019

Abstract

Chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), is a skin disease responsible for the global decline of amphibians. Frog species and populations can vary in susceptibility, but this phenomenon remains poorly understood. Here, we investigated serotonin in the skin of infected and uninfected frogs. In more susceptible frog populations, skin serotonin rose with increasing infection intensity, but decreased in later stages of the disease. The more resistant population maintained a basal level of skin serotonin. Serotonin inhibited both Bd sporangial growth and Jurkat lymphocyte proliferation in vitro. However, serotonin accumulates in skin granular glands, and this co..

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Grants

Awarded by Australian Research Council


Funding Acknowledgements

Queensland Government; Taronga Conservation Society; National Collaborative Research Infrastructure Strategy; Australian Wildlife Society; Wet Tropics Management Authority; Australian Research Council, Grant/Award Numbers: DP120100811, FT100100375 and LP110200240; IUCN; U.S. Fish and Wildlife Service