Journal article

Sarcopenia, Cerebral Palsy, and Botulinum Toxin Type A

Iqbal Multani, Jamil Manji, Min Jia Tang, Walter Herzog, Jason J Howard, H Kerr Graham

JBJS REVIEWS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

Sarcopenia is common in both the elderly and children with cerebral palsy. Children with cerebral palsy have muscles that are much smaller than muscles in typically developing peers. Injections of botulinum toxin type A (BoNT-A) result in acute muscle atrophy in animal models and in human subjects. It is not known when or if muscles recover fully after injection of BoNT-A. These findings have implications for management protocols.