The role of insulin-like growth factor 2 receptor-mediated homeobox gene expression in human placental apoptosis, and its implications in idiopathic fetal growth restriction
Lynda K Harris, Priyadarshini Pantham, Hannah EJ Yong, Anita Pratt, Anthony J Borg, Ian Crocker, Melissa Westwood, John Aplin, Bill Kalionis, Padma Murthi
MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2019
Fetal growth restriction (FGR) is caused by poor placental development and function early in gestation. It is well known that placentas from women with FGR exhibit reduced cell growth, elevated levels of apoptosis and perturbed expression of the growth factors, cytokines and the homeobox gene family of transcription factors. Previous studies have reported that insulin-like growth factor-2 (IGF2) interacts with its receptor-2 (IGF2R) to regulate villous trophoblast survival and apoptosis. In this study, we hypothesized that human placental IGF2R-mediated homeobox gene expression is altered in FGR and contributes to abnormal trophoblast function. This study was designed to determine the associ..View full abstract
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Awarded by BBSRC
Awarded by National Health and Medical Research Council (NHMRC)
The Castang Foundation; LKH is a BBSRC David Phillips Research Fellow (BB/H022627/1); National Health and Medical Research Council (NHMRC) project grant support #509140 awarded to PM; The Maternal and Fetal Health Research Centre is supported by funding from Tommy's the Baby Charity, an Action Research Endowment Fund, the Manchester Biomedical Research Centre and the Greater Manchester Comprehensive Local Research Network.