Journal article

Gastrointestinal carriage is a major reservoir of K. pneumoniae infection in intensive care patients

Claire Gorrie, Mirjana Mirceta, Ryan Wick, David Edwards, Richard Strugnell, Nigel Pratt, Jill Garlick, Kerrie Watson, David Pilcher, Steven McGloughlin, Denis Spelman, Adam Jenney, Kathryn Holt

Published : 2016


Abstract Background Klebsiella pneumoniae is an opportunistic pathogen and a leading cause of hospital-associated (HA) infections. Patients in intensive care units (ICUs) are particularly at risk, and outbreaks are frequently reported in ICUs. K. pneumoniae is also part of the healthy human microbiome, providing a potential reservoir for HA infection. However, the frequency of K. pneumoniae gut colonization and its contribution to HA infections are not well characterized. Methods We conducted one-year prospective cohort study of ICU patients. Participants (n=498) were screened for rectal and throat carriage of K. pneumoniae shortly after admission, and clinical information was extracted from..

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