Journal article

Restoration of microRNA-29c in type I endometrioid cancer reduced endometrial cancer cell growth

Michelle Van Sinderen, Meaghan Griffiths, Ellen Menkhorst, Keith Niven, Evdokia Dimitriadis

ONCOLOGY LETTERS | SPANDIDOS PUBL LTD | Published : 2019

Abstract

Endometrial cancer is the most common gynaecological cancer worldwide, and the prognosis of patients with advanced disease remains poor. MicroRNAs (miRs) are dysregulated in endometrial cancer. miRs-29-a, -b and -c expression levels are downregulated in endometrial cancer; however, a specific role for miR-29c and its target genes remain to be elucidated. The aim of the present study was to determine the functional effect of restoring miR-29c expression in endometrial cancer cell lines and to identify miR-29c targets involved in cancer progression. miR-29c expression in human endometrial tumour grades 1-3 and benign tissue as well as in the endometrial cancer cell lines Ishikawa, HEC1A and AN..

View full abstract

Grants

Awarded by National Health and Medical Research Council (Australia) Senior Research Fellowship


Funding Acknowledgements

The present study was supported by the Victorian Government's Operational Infrastructure Support Program. ED was supported by The National Health and Medical Research Council (Australia) Senior Research Fellowship (grant no. 550905).