Contribution of Genome-Wide Significant Single Nucleotide Polymorphisms in Myopia Prediction Findings from a 10-year Cohort of Chinese Twin Children
Yanxian Chen, Xiaotong Han, Xiaobo Guo, Yonghui Li, Jonathan Lee, Mingguang He
OPHTHALMOLOGY | ELSEVIER SCIENCE INC | Published : 2019
PURPOSE: To determine the added predictive ability of genome-wide significant single nucleotide polymorphisms (SNPs) in refraction prediction in children and investigate the earliest age threshold for an accurate prediction of high myopia. DESIGN: Prospective longitudinal study. PARTICIPANTS: A total of 1063 first-born twins followed annually between 2006 and 2015 in China. The exposures were genetic factors (parental myopia, SNPs) and environmental factors (near work, outdoor activity). METHODS: Five linear mixed-effect models, consisting of different combinations of age, gender, genetic, and environmental factors, were built to predict myopia development. All predictions were performed on ..View full abstract
Awarded by National Natural Science Foundation of China
Awarded by Science and Technology Planning Project of Guangdong Province, China
Awarded by China Postdoctoral Science Foundation
Supported by the Fundamental Research Funds of the State Key Laboratory in Ophthalmology, National Natural Science Foundation of China 81125007, Science and Technology Planning Project of Guangdong Province, China 2013B20400003, China Postdoctoral Science Foundation (2019TQ0365).