A multimodal MRI study of the neural mechanisms of emotion regulation impairment in women with obesity

Trevor Steward; Maria Pico-Perez; Gemma Mestre-Bach; Ignacio Martinez-Zalacain; Maria Sunol; Susana Jimenez-Murcia; Jose A Fernandez-Formoso; Nuria Vilarrasa; Amador Garcia-Ruiz-de-Gordejuela; Misericordia Veciana de las Heras; Nuria Custal; Nuria Virgili; Rafael Lopez-Urdiales; Jose M Menchon; Roser Granero; Carles Soriano-Mas; Fernando Fernandez-Aranda

Journal article

A multimodal MRI study of the neural mechanisms of emotion regulation impairment in women with obesity

Trevor Steward, Maria Pico-Perez, Gemma Mestre-Bach, Ignacio Martinez-Zalacain, Maria Sunol, Susana Jimenez-Murcia, Jose A Fernandez-Formoso, Nuria Vilarrasa, Amador Garcia-Ruiz-de-Gordejuela, Misericordia Veciana de las Heras, Nuria Custal, Nuria Virgili, Rafael Lopez-Urdiales, Jose M Menchon, Roser Granero, Carles Soriano-Mas, Fernando Fernandez-Aranda

TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2019

DOI: 10.1038/s41398-019-0533-3

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Abstract

Maladaptive emotion regulation contributes to overeating and impedes weight loss. Our study aimed to compare the voluntary downregulation of negative emotions by means of cognitive reappraisal in adult women with obesity (OB) and female healthy controls (HC) using a data-driven, multimodal magnetic resonance imaging (MRI) approach. Women with OB (n = 24) and HC (n = 25) carried out an emotion regulation task during functional MRI scanning. Seed-to-voxel resting-state connectivity patterns derived from activation peaks identified by this task were compared between groups. Diffusion tensor imaging (DTI) was used to examine white matter microstructure integrity between regions exhibiting group ..

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University of Melbourne Researchers

Trevor Steward Author Melbourne School of Psychological Sciences

Grants

Awarded by Instituto de Salud Carlos III (ISCIII)

Awarded by AGAUR

Awarded by P-FIS Carlos III grant

Awarded by CIBERSAM PhD grant

Awarded by Miguel Servet contract from the Carlos III Health Institute

Awarded by Department of Health of the Generalitat de Catalunya from the call "Accio instrumental de programes de recerca orientats en l'ambit de la recerca i la innovacio en salut"

Awarded by EU

Funding Acknowledgements

This manuscript and research was supported by a grant from the Instituto de Salud Carlos III (ISCIII) (FIS PI14/00290, PI17/01167; PI13/01958) and co-funded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe. CIBERobn and CIBERsam are both initiatives of ISCIII. M.P.-P. and G.M.-B. are supported by predoctoral AGAUR grants (2015 FI_B 00839 and 2018 FI_B2 00174), grants co-funded by the European Social Fund (ESF) "ESF", investing in your future. I.M.-Z. receives support from a P-FIS Carlos III grant (FI17/00294). M.S. is supported by a CIBERSAM PhD grant (CNV665/914). C.S.-M. is supported by a Miguel Servet contract from the Carlos III Health Institute (CPII16/00048). Study resulting from the SLT006/17/00246 grant, funded by the Department of Health of the Generalitat de Catalunya from the call "Accio instrumental de programes de recerca orientats en l'ambit de la recerca i la innovacio en salut". We thank CERCA Program/Generalitat de Catalunya for institutional support. Additional support received from EU Grant Eat2beNice (H2020-SFS-2016-2; Ref 728018).