Journal article
A multimodal MRI study of the neural mechanisms of emotion regulation impairment in women with obesity
T Steward, M Picó-Pérez, G Mestre-Bach, I Martínez-Zalacaín, M Suñol, S Jiménez-Murcia, JA Fernández-Formoso, N Vilarrasa, A García-Ruiz-de-Gordejuela, M Veciana de las Heras, N Custal, N Virgili, R Lopez-Urdiales, JM Menchón, R Granero, C Soriano-Mas, F Fernandez-Aranda
Translational Psychiatry | NATURE PUBLISHING GROUP | Published : 2019
Abstract
Maladaptive emotion regulation contributes to overeating and impedes weight loss. Our study aimed to compare the voluntary downregulation of negative emotions by means of cognitive reappraisal in adult women with obesity (OB) and female healthy controls (HC) using a data-driven, multimodal magnetic resonance imaging (MRI) approach. Women with OB (n = 24) and HC (n = 25) carried out an emotion regulation task during functional MRI scanning. Seed-to-voxel resting-state connectivity patterns derived from activation peaks identified by this task were compared between groups. Diffusion tensor imaging (DTI) was used to examine white matter microstructure integrity between regions exhibiting group ..
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Awarded by Horizon 2020 Framework Programme
Funding Acknowledgements
This manuscript and research was supported by a grant from the Instituto de Salud Carlos III (ISCIII) (FIS PI14/00290, PI17/01167; PI13/01958) and co-funded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe. CIBERobn and CIBERsam are both initiatives of ISCIII. M.P.-P. and G.M.-B. are supported by predoctoral AGAUR grants (2015 FI_B 00839 and 2018 FI_B2 00174), grants co-funded by the European Social Fund (ESF) "ESF", investing in your future. I.M.-Z. receives support from a P-FIS Carlos III grant (FI17/00294). M.S. is supported by a CIBERSAM PhD grant (CNV665/914). C.S.-M. is supported by a Miguel Servet contract from the Carlos III Health Institute (CPII16/00048). Study resulting from the SLT006/17/00246 grant, funded by the Department of Health of the Generalitat de Catalunya from the call "Accio instrumental de programes de recerca orientats en l'ambit de la recerca i la innovacio en salut". We thank CERCA Program/Generalitat de Catalunya for institutional support. Additional support received from EU Grant Eat2beNice (H2020-SFS-2016-2; Ref 728018).