Conference Proceedings
Copy number analysis identifies ESR1 and MDM4 as drivers of progression in invasive lobular breast carcinoma
JM Atkinson, L Cao, A Basudan, MJ Sikora, A Bahreini, N Tasdemir, RC Jankowitz, PF McAuliffe, D Dabbs, S Haupt, Y Haupt, PC Peter Lucas, AV Lee, S Oesterreich
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2019
Abstract
Abstract Background: Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer after invasive ductal carcinoma (IDC). While specific clinical and pathological features differ between ILC and IDC, both histologies are treated the same, due to a lack of knowledge of targetable pathways underlying the observed differences. To identify potential genetic drivers of ILC progression, we set out to identify genes with copy number (CN) alterations, comparing tumors with good outcome to those with poor outcome. Method: We designed probes for a total of 67 genes known to be frequently altered in breast cancer and used sensitive nanoSt..
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