Inhibition of Influenza A Virus by Human Infant Saliva
Brad Gilbertson, Kathryn Edenborough, Jodie McVernon, Lorena E Brown
VIRUSES-BASEL | MDPI | Published : 2019
Innate antiviral factors in saliva play a role in protection against respiratory infections. We tested the anti-influenza virus activities of saliva samples taken from human infants, 1-12 months old, with no history of prior exposure to influenza. In contrast to the inhibitory activity we observed in mouse and ferret saliva, the activity of human infant saliva was complex, with both sialic acid-dependent and independent components, the proportion of which differed between individuals. Taken as a whole, we showed that the major anti-influenza activity of infant saliva is acquired over the first year of life and is associated with sialic acid-containing molecules. The activity of sialic acid-i..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This research was funded by a National Health and Medical Research Council of Australia Program grant, ID1071916 and Project grant, 509281.