Journal article

Emerging strategies in the initial management of locally advanced rectal cancer

Lucy Gately, Hui-Li Wong, Jeanne Tie, Rachel Wong, Margaret Lee, Belinda Lee, Azim Jalali, Peter Gibbs

Future Oncology | FUTURE MEDICINE LTD | Published : 2019


The initial management of locally advanced rectal cancer continues to evolve and formulating the ideal treatment plan remains challenging, with a multitude of emerging treatment strategies and either limited or inconsistent data to support these. The main objective of neoadjuvant treatment is to maximize disease control and minimize toxicity and impact on quality of life. Ultimately, the optimal approach needs to be personalized to the individual. In this Review, we discuss the various strategies currently used and being further investigated in the initial treatment of patients presenting with locally advanced rectal cancer. We describe the evidence behind the current standard of care recomm..

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