A systematic review of the cost-effectiveness of uterotonic agents for the prevention of postpartum hemorrhage

Abstract

Background: Several uterotonic options exist for prevention of postpartum hemorrhage (PPH); hence, cost-effectiveness is an important decision-making criterion affecting uterotonic choice. Objective: To conduct a systematic review of cost-effectiveness of uterotonics for PPH prevention to support a WHO guideline update. Search strategy: We searched major databases from 1980 to June 2018 and the National Health Services Economic Evaluation (NHS EED) database from inception (1995) to March 2015 for eligible studies. Selection criteria: We included comparative economic evaluations, cost-utility analyses, and resource-utilization studies. Data collection and analysis: Two reviewers independently..