Journal article

Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis

ID Gallos, A Papadopoulou, R Man, N Athanasopoulos, A Tobias, MJ Price, MJ Williams, V Diaz, J Pasquale, M Chamillard, M Widmer, O Tuncalp, GJ Hofmeyr, F Althabe, AM Gulmezoglu, JP Vogel, OT Oladapo, A Coomarasamy

Cochrane Database of Systematic Reviews | WILEY | Published : 2018

Abstract

BACKGROUND: Postpartum haemorrhage (PPH) is the leading cause of maternal mortality worldwide. Prophylactic uterotonic agents can prevent PPH, and are routinely recommended. The current World Health Organization (WHO) recommendation for preventing PPH is 10 IU (international units) of intramuscular or intravenous oxytocin. There are several uterotonic agents for preventing PPH but there is still uncertainty about which agent is most effective with the least side effects. This is an update of a Cochrane Review which was first published in April 2018 and was updated to incorporate results from a recent large WHO trial. OBJECTIVES: To identify the most effective uterotonic agent(s) to prevent P..

View full abstract

Grants

Awarded by UK National Institute for Health Research (Health Technology Assessment Project)


Awarded by Ammalife (UK Registered Charity)


Funding Acknowledgements

University of Birmingham, UK.r The authors of this review are employed by the institutions indicated by their respective affiliations except where otherwise stated.r World Health Organization, Switzerland.r The authors of this review are employed by the institutions indicated by their respective affiliations except where otherwise stated.r University of the Witwatersrand, South Africa.r The authors of this review are employed by the institutions indicated by their respective affiliations except where otherwise stated.r National Institute for Health Research, UK.r This review is undertaken as part of independent research funded by the UK National Institute for Health Research (Health Technology Assessment Project 14/139/17 Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis and cost-effectiveness analysis).r Birmingham Women's NHS Foundation Trust, UK.r Additional financial support to meet the employment costs of Helen M Willliams (HMW) and Abi Merriel (AM) is provided by Birmingham Women's NHS Foundation Trust.r Ammalife, UK.r Additional financial support to meet the employment costs of Abi Merriel (AM) is provided by Ammalife (UK Registered Charity 1120236).