Journal article

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T Chan, Natalie Brajanovski, Lorey K Smith, Aparna D Rao, Emily J Lelliott, Margarete Kleinschmidt, Ismael A Vergara, Anthony T Papenfuss, Peter Lau, Prerana Ghosh, Sue Haupt Show all

Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2019


Awarded by Cancer Council Victoria

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

We thank the staff of the following Peter MacCallum Cancer Centre core facilities: the Victorian Centre for Functional Genomics; the Molecular Genomics facility; and the Flow Cytometry facility. We thank the MD Anderson RPPA core facility for performing the RPPA screening. We thank Rachael Walker and Susan Jackson for assisting in the in vivo study. We thank Dr. Maria Doyle (Research Computing) for bioinformatic assistance. We thank Associate Professor Marco Herold (Walter and Eliza Hall Institute) for providing the MDM4 silencing vector; Dr. Gareth Gregory and Prof. Ricky Johnston for providing CDK2 shRNA constructs; and Prof. Shereen Loi, Dr. Joyce Teo, Prof. Wayne Phillips, and Dr. Nicholas Clemmens for providing breast, pancreatic, and esophageal cancer cell lines. We thank Dr. Twishi Gulati for editorial assistance. We acknowledge Cancer Therapeutics CRC for partly funding the in vivo studies. This work was supported by the Peter MacCallum Cancer Foundation; and by Cancer Council Victoria Grant 1108149 and National Health and Medical Research Council of Australia Grant 1042986 (to K. E. S. and G. A. M.). S. A. was supported by doctoral scholarships from the University of Melbourne and Cancer Therapeutics CRC.