Journal article

On the neural basis of deep brain stimulation evoked resonant activity

Nicholas C Sinclair, James B Fallon, Kristian J Bulluss, Wesley Thevathasan, Hugh J McDermott



Objective: Deep brain stimulation can be a remarkably effective treatment for Parkinson's disease and other conditions; however, an electrophysiological feedback signal is needed to improve surgical accuracy and for optimising therapy according to patient needs. Evoked responses may provide such a signal, although it is crucial to determine that recorded potentials are of neural origin and not a consequence of stimulation artefacts. Here, we use several in vitro and in vivo methods to establish the neural basis of resonant deep brain stimulation evoked activity. Approach: Recordings were obtained from deep brain stimulation electrodes in saline, in feline brain regions not expected to produc..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

San San Xu, Angus Begg, and Nicola Horvath assisted with the clinical recordings and Nicole Critch and Catherine Gaunt assisted with animal maintenance. This work was supported by the Colonial Foundation, St Vincent's Hospital Research Endowment Fund, and the National Health and Medical Research Council (project grant #1103238, development grant #1113680). The Bionics Institute acknowledges the support it receives from the Victorian Government through its operational infrastructure program. N C S is supported through an Australian Government Research Training Program Scholarship. W T is supported by Lions International and the National Health and Medical Research Council.