Journal article
Parkinson's disease in the Western Pacific Region
SY Lim, AH Tan, A Ahmad-Annuar, C Klein, LCS Tan, RL Rosales, R Bhidayasiri, YR Wu, HF Shang, AH Evans, PK Pal, N Hattori, CT Tan, B Jeon, EK Tan, AE Lang
Lancet Neurology | ELSEVIER SCIENCE INC | Published : 2019
Abstract
1·8 billion people of diverse ethnicities and cultures live in the Western Pacific Region. The increasing longevity of populations in this region is a major contributor to the exponential increase in Parkinson's disease prevalence worldwide. Differences exist between Parkinson's disease in the Western Pacific Region and in Europe and North America that might provide important insights into our understanding of the disease and approaches to management. For example, some genetic factors (such as LRRK2 mutations or variants) differ, environmental exposures might play differential roles in modulating the risk of Parkinson's disease, and fewer dyskinesias are reported, with some differences in th..
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Funding Acknowledgements
We gratefully acknowledge the following individuals for providing data or insights from their respective countries or territories, or areas of expertise: Mandy Auyeung (Hong Kong), Samleng Chan (Cambodia), Victor SC Fung (Australia), Taku Hatano (Japan), Seong-Beom Koh (Parkinson's disease epidemiology in South Korea), Minh Le (Vietnam), Woong-Woo Lee (Parkinson's disease epidemiology in South Korea), Angus Macleod (Parkinson's disease epidemiology and mortality), Connie Marras (University of Toronto, ON, Canada) (Parkinson's disease epidemiology in North America), Victor McConvey (Australia; Allied health care), Vincent Chung Tong Mok (Hong Kong), Elena Moro (DBS), Weerasak Muangpaisan (Parkinson's disease epidemiology), Emma Nichols (Institute for Health Metrics and Evaluation; Global Burden of Disease), Yasushi Osaki (Parkinson's disease epidemiology in Japan), Eric Roberts (Public Health Institute, CA, USA, and the Parkinson's Foundation P4 group; Parkinson's disease epidemiology), Mark Simpson (New Zealand), Yu Sun (Parkinson's disease epidemiology in Taiwan), Frandy Susatia (Indonesia), Tran Ngoc Tai (Vietnam), Yeremia Tatang (Indonesia), Wesley Thevathasan (DBS in Australia), Bayasgalan Tserensodnom (Mongolia), and Somchit Vorachit (Laos). S-YL and AHT obtained funding from the University of Malaya Parkinson's Disease and Movement Disorders Research Program Fund (PV035-2017) for M G Rudakewich (Synapse Visuals, Edmonton, AB, Canada) to produce figures 1 and 2. E-KT acknowledges support from the National Medical Research Council, Singapore (STaR and Singapore Parkinson's Disease Programme Grant [SPARK 1 & 2]). Funding sources had no involvement in the writing of the manuscript or the decision to submit for publication.