Conference Proceedings
Immune parameters associated with survival in triple negative and HER2-positive breast cancer patients with 10 years of follow-up
C Solinas, A de Wind, G Van den Eynden, L Ameye, S Garaud, P De Silva, A Boisson, G Noel, M Langouo Fontsa, L Buisseret, E de Azambuja, PA Francis, A Di Leo, JP Crown, C Sotiriou, D Larsimont, M Paesmans, M Piccart-Gebhart, K Willard-Gallo
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2019
Abstract
Abstract The clinical utility of tumor-infiltrating lymphocytes (TIL) is actively being investigated in breast cancer (BC). It is unclear whether TIL spatial location and organization in tertiary lymphoid structures (TLS) have an impact on prognosis. Additionally, the significance of PD-1 and PD-L1 expression is being debated due to conflicting data from several studies. We hypothesize that the presence, extent and spatial location of multiple immune biomarkers, reflecting ongoing immune responses, will be consistently associated with a good prognosis in highly infiltrated BC [triple-negative (TNBC) and HER2+]. The relationship between these immune biomarkers an..
View full abstract