Journal article
BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2
MS Cline, RG Liao, MT Parsons, B Paten, F Alquaddoomi, A Antoniou, S Baxter, L Brody, R Cook-Deegan, A Coffin, FJ Couch, B Craft, R Currie, CC Dlott, L Dolman, JT den Dunnen, SOM Dyke, SM Domchek, D Easton, Z Fischmann Show all
Plos Genetics | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly collaborative research activities. Its goal is to generate an informed and current understanding of the impact of genetic variation on cancer risk across the iconic cancer predisposition genes, BRCA1 and BRCA2. Initially, reported variants in BRCA1 and BRCA2 available from public databases were integrated into a single, newly created site, www.brcaexchange.org. The purpose of the BRCA Exchange is to provide the community with a reliable and easily accessible record of variants interpreted for a high-penetrance phenotyp..
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Awarded by National Human Genome Research Institute
Funding Acknowledgements
Partial Funding from Intramural Research Program, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, MD, Partial Funding from Beau Biden Moonshot Act, ABS is supported by an NHMRC Senior Research Fellowship (ID1061779), AT and BMK are supported by Can-SHARE. Can-SHARE is supported by Genome Quebec, Genome Canada, the government of Canada, the Ministere de l'Economie, Innovation et Exportation du Quebec, and the Canadian Institutes of Health Research (fund #141210), (http://www.p3g.org/resources/can-share), BC and MJG are supported by awards 5U24CA180951-05 and 5U24CA210974-02 from the National Cancer Institute's ITCR program (https://itcr.cancer.gov/), BC-D is supported by R01 HG 008918 "Building the Medical Information Commons" from the National Human Genome Research Institute (genome. gov), BP and MC are supported by grant U54HG007990 from the National Human Genome Research Institute (genome.gov), GR is supported by ETH Zurich (core) funding, JB is supported by an educational grant from AstraZeneca, HLR is supported by ClinGen grant U41HG006834 (www.clinicalgenome.org), MR is supported by the Breast Cancer Research Foundation (https://www.bcrf.org/) and an MSKCC Cancer Center Support grant/Core grant P30 CA008748 (https://www.mskcc.org/), RGL is supported by grant U24CA210999 from the National Cancer Institute (cancer.gov) and grant U01HG008676 from the National Human Genome Research Institute (genome.gov), SD is supported by the Basser Center for BRCA (Philadelphia, PA), SEP is supported by grant 1U41HG009649, and WDF is supported by FDN-148390 from Canadian Institutes of Health Research (http://www.cihr-irsc.gc.ca). The funders had no role in the preparation of the article.