Journal article

Olfactory sulcus morphology in teenagers with first-presentation borderline personality disorder

Tsutomu Takahashi, Yumiko Nishikawa, Dennis Velakoulis, Michio Suzuki, Patrick D McGorry, Christos Pantelis, Andrew M Chanen

PSYCHIATRY RESEARCH-NEUROIMAGING | ELSEVIER IRELAND LTD | Published : 2019

Abstract

Gray matter reduction of the orbitofrontal cortex (OFC) has been reported in borderline personality disorder (BPD), but it remains unknown whether the BPD patients exhibit morphologic changes of the olfactory sulcus, a potential marker of forebrain development located on the OFC. We used magnetic resonance imaging to investigate the length and depth of the olfactory sulcus in 20 teenagers (15 females and 5 males) with first-presentation BPD and 20 healthy controls (15 females and 5 males). While there was no group difference in the length of the sulcus, the BPD patients (especially those with a history of trauma) had a significantly shallower right olfactory sulcus compared with controls. In..

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Grants

Awarded by JSPS KAKENHI


Awarded by Health and Labour Sciences Research Grants for Comprehensive Research on Persons with Disabilities from Japan Agency for Medical Research and Development (AMED)


Awarded by NHMRC Senior Principal Research Fellowship


Funding Acknowledgements

This research was supported by JSPS KAKENHI Grant Number JP18K07550 to TT and JP24390281 to MS, and by the Health and Labour Sciences Research Grants for Comprehensive Research on Persons with Disabilities from Japan Agency for Medical Research and Development (AMED) Grant Number 16dk0307029h0003 to MS. CP was supported by a NHMRC Senior Principal Research Fellowship (1105825). None of the funding sources had any role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. The authors thank the staff of the HYPE Clinic at ORYGEN Youth Health.