Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

AJ Vogrin; NI Bower; MJ Gunzburg; S Roufail; KS Okuda; S Paterson; SJ Headey; SA Stacker; BM Hogan; MG Achen

Journal article

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

AJ Vogrin, NI Bower, MJ Gunzburg, S Roufail, KS Okuda, S Paterson, SJ Headey, SA Stacker, BM Hogan, MG Achen

Cell Reports | CELL PRESS | Published : 2019

DOI: 10.1016/j.celrep.2019.07.055

Abstract

Lymphatic vessels display organotypic function and develop in an organ-specific manner. Vogrin et al. find that the zebrafish Kdr receptor is indispensible for craniofacial, but not trunk, lymphangiogenesis whereas Flt4 is essential for the latter. Thus, vascular endothelial growth factor (VEGF) receptor signaling pathways are differentially employed in different tissues to drive developmental lymphangiogenesis.

University of Melbourne Researchers

Kazuhide Okuda Author

Steven Stacker Author

Benjamin Hogan Author

Marc Achen Author

Grants

Funding Acknowledgements

Imaging was performed at the Australian Cancer Research Foundation's Cancer Ultrastructure and Function Facility, Institute for Molecular Bioscience, University of Queensland. This work was supported by grants and a research fellowship from the National Health and Medical Research Council of Australia (NHMRC), and by the University of Queensland's Centre for Cardiac and Vascular Biology and the Operational Infrastructure Program of the Victorian government. B.M.H. was supported by a National Heart Foundation/NHMRC Career Development Fellowship.