Journal article

Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis

Florian Javelle, Amit Lampit, Wilhelm Bloch, Peter Haeussermann, Sheri L Johnson, Philipp Zimmer

Nutrition Reviews | OXFORD UNIV PRESS INC | Published : 2020


CONTEXT: Serotonergic dysfunction, including reduced central serotonin levels, is associated with different psychiatric syndromes, including depression. As a serotonin precursor, 5-hydroxytryptophan has long been used as a nonpharmacological treatment for depression. OBJECTIVE: A systematic review and meta-analysis was conducted to determine the antidepressant effects of 5-hydroxytryptophan in depressed patients. DATA SOURCES: MEDLINE (via PubMed) and Google Scholar were searched from inception to May 2018. DATA EXTRACTION: Thirteen investigations were included in the systematic review (using PRISMA guidelines), and 7 in the full meta-analysis (pre-registered on PROSPERO: CRD42018104415). DA..

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University of Melbourne Researchers