Journal article
Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease
G Goel, JA Tye-Din, SW Qiao, AK Russell, T Mayassi, C Ciszewski, VK Sarna, S Wang, KE Goldstein, JL Dzuris, LJ Williams, RJ Xavier, KEA Lundin, B Jabri, LM Sollid, RP Anderson
Science Advances | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2019
Abstract
Celiac disease (CeD), caused by immune reactions to cereal gluten, is treated with gluten -elimination diets. Within hours of gluten exposure, either perorally or extraorally by intradermal injection, treated patients experience gastrointestinal symptoms. To test whether gluten exposure leads to systemic cytokine production time -related to symptoms, series of multiplex cytokine measurements were obtained in CeD patients after gluten challenge. Peptide injection elevated at least 15 plasma cytokines, with IL-2, IL-8, and IL-10 being most prominent (fold-change increase at 4 hours of 272, 11, and 1.2, respectively). IL-2 and IL-8 were the only cytokines elevated at 2 hours, preceding onset of..
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Awarded by National Institute of Diabetes and Digestive and Kidney Diseases
Funding Acknowledgements
G.G. and R.J.X. were supported by The Paul and Kathy Severino Research Fund. S.-W.Q., K.E.A.L., and L.M.S. were supported by the Research Council of Norway (grant 179573/V40 through its Centre of Excellence funding scheme), the South-Eastern Norway Regional Health Authority (grant 2013046), and the Stiftelsen KG Jebsen (SKGH-MED-017). B.J. and T.M. were supported by grants from the Digestive Diseases Research Core Center (DK42086) at the University of Chicago and from the U.S. NIH (RO1DK67180 and R01DK098435 to B.J.). J.A.T.-D. was supported by the Mathison Centenary Fellowship, University of Melbourne.