Journal article

Intra-articular Treatment of Osteoarthritis with Diclofenac-Conjugated Polymer Reduces Inflammation and Pain

A Sulistio, FM Mansfeld, F Reyes-Ortega, AM D'Souza, SMY Ng, S Birkett, A Blencowe, GG Qiao, CB Little, CC Shu, AM Bendele, D Valade, AC Donohue, JF Quinn, MR Whittaker, TP Davis, RJ Tait

ACS Applied Bio Materials | American Chemical Society | Published : 2019

Abstract

The most common treatment for osteoarthritis is daily oral administration of a nonsteroidal anti-inflammatory drug such as diclofenac. This daily dosage regime is often associated with severe side effects. In this study, we explored the potential of utilizing a high molecular weight cross-linked polyurethane polymer covalently linked to diclofenac (C-DCF-PU) for intra-articular administration. We aim to exploit the advantages of local drug delivery by developing an implant with improved efficacy and reduced side effects. The polymer was synthesized from a diclofenac-functionalized monomer unit in a simple one-pot reaction, followed by cross-linking. In vitro drug release studies showed zero-..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council


Funding Acknowledgements

This collaborative research was conducted by PolyActiva Pty Ltd, University of Melbourne (ARC Linkage Grant No. LP12020010) and the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036) (ARC Linkage Grant No. LP140100284). T.P.D. wishes to acknowledge the award of an Australian Laureate Fellowship.