Journal article

Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis

Tina D Kristensen, Rene CW Mandl, Jayachandra M Raghaya, Kasper Jessen, Jens Richardt M Jepsen, Birgitte Fagerlunc, Louise B Glenthoj, Christina Wennebere, Kristine Krakauer, Christos Pantelis, Merete Nordentoft, Birte Y Glenthoj, Bjorn H Ebdrup

HUMAN BRAIN MAPPING | WILEY | Published : 2019

Abstract

In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional white matter and cognitive functions in individuals at ultra-high risk for psychosis. One hundred and sixteen individuals at ultra-high risk for psychosis and 49 matched healthy controls underwent 3 T magnetic resonance diffusion-weighted imaging and cognitive assessments. Group differences on fractional anisotropy were tested using tract-based spatial statistics. Group differences in cognitive functions, voxel-wise as well as regional fractional anisotropy were tested using univariate general linear modeling..

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University of Melbourne Researchers