The Protective Effect of Zinc Against Liver Ischaemia Reperfusion Injury in a Rat Model of Global Ischaemia
Ernest Cheung, Mehrdad Nikfarjam, Louise Jackett, Damien M Bolton, Joseph Ischia, Oneel Patel
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY | ELSEVIER - DIVISION REED ELSEVIER INDIA PVT LTD | Published : 2020
Background: Ischaemia-reperfusion injury (IRI) is a major obstacle during liver transplantation and resection surgeries for cancer, with a need for effective and safe drugs to reduce IRI. Zinc preconditioning has been shown to protect against liver IRI in a partial (70%) ischaemia model. However, its efficacy against a clinically relevant Pringle manoeuvre that results in global liver ischaemia (100%) is unknown. Aims: The aim of this study was to test the efficacy of zinc preconditioning in a rat model of global liver ischaemia. Methods: Rats were preconditioned via subcutaneous injection of 10 mg/kg of ZnCl2, 24 h and 4 h before ischaemia. Total liver ischaemia (100%) was induced by placin..View full abstract
This work was in part supported by the Austin Medical Research Foundation (AMRF) and by University of Melbourne.