ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
Steven Goossens, Jueqiong Wang, Cedric S Tremblay, Jelle De Medts, Sara T'Sas, Nguyen Thao, Jesslyn Saw, Katharina Haigh, David J Curtis, Pieter Van Vlierberghe, Geert Berx, Tom Taghon, Jody J Haigh
Haematologica: the hematology journal | FERRATA STORTI FOUNDATION | Published : 2019
ZEB1 and ZEB2 are structurally related E-box binding homeobox transcription factors that induce epithelial to mesenchymal transitions during development and disease. As such, they regulate cancer cell invasion, dissemination and metastasis of solid tumors. In addition, their expression is associated with the gain of cancer stem cell properties and resistance to therapy. Using conditional loss-of-function mice, we previously demonstrated that Zeb2 also plays pivotal roles in hematopoiesis, controlling important cell fate decisions, lineage commitment and fidelity. In addition, upon Zeb2 overexpression, mice spontaneously develop immature T-cell lymphoblastic leukemia. Here we show that pre-le..View full abstract
Awarded by Australian NHMRC
This work was supported by the Australian NHMRC (grant 1047995 to JJH), the Worldwide Cancer Research Fund, the Swiss Bridge Foundation, Stand Up Against Cancer Fund, the Ghent University Special Research Fund and the Fund for Scientific Research-Flanders.