Journal article

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

Steven Goossens, Jueqiong Wang, Cedric S Tremblay, Jelle De Medts, Sara T'Sas, Nguyen Thao, Jesslyn Saw, Katharina Haigh, David J Curtis, Pieter Van Vlierberghe, Geert Berx, Tom Taghon, Jody J Haigh

Haematologica: the hematology journal | FERRATA STORTI FOUNDATION | Published : 2019

Abstract

ZEB1 and ZEB2 are structurally related E-box binding homeobox transcription factors that induce epithelial to mesenchymal transitions during development and disease. As such, they regulate cancer cell invasion, dissemination and metastasis of solid tumors. In addition, their expression is associated with the gain of cancer stem cell properties and resistance to therapy. Using conditional loss-of-function mice, we previously demonstrated that Zeb2 also plays pivotal roles in hematopoiesis, controlling important cell fate decisions, lineage commitment and fidelity. In addition, upon Zeb2 overexpression, mice spontaneously develop immature T-cell lymphoblastic leukemia. Here we show that pre-le..

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