Journal article

Purified beta-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota

Junqiu Luo, Daiwen Chen, Xiangbing Mao, Jun He, Bing Yu, Long Cheng, Dafu Zeng

ANIMALS | MDPI | Published : 2019

Abstract

This study investigated β-glucan derived from Agrobacterium sp. ZX09 with high (2000 kDa) and low (300 kDa) molecular weight (MW) to compare their effects on growth performance and gut function in LPS-induced weaned piglets. Changes in jejunal morphology, mucosal barrier function, microbial populations, and fermentation in the piglets were determined. Data showed that β-glucan prevented body weight loss in LPS challenged piglets. Supplementation with both β-glucan fractions improved jejunal morphology. Compared to low MW, β-glucan of high MW generally up-regulated transcripts of ZO-1, MUC1, and MUC2 in jejunal mucosa to a lesser extent. Mucosal D-lactate, diamine oxidase, and anti-oxidation ..

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University of Melbourne Researchers

Grants

Awarded by National Natural Science Foundation of China


Awarded by International Science and Technology Cooperation Foundation, Sichuan, China


Funding Acknowledgements

This research was supported by a grant from the National Natural Science Foundation of China (31702124) and the International Science and Technology Cooperation Foundation, Sichuan, China (2016HH0004).