Journal article
Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy
K Silvennoinen, N de Lange, S Zagaglia, S Balestrini, G Androsova, M Wassenaar, P Auce, A Avbersek, F Becker, B Berghuis, E Campbell, A Coppola, B Francis, S Wolking, GL Cavalleri, J Craig, N Delanty, MR Johnson, BPC Koeleman, WS Kunz Show all
Epilepsia Open | WILEY | Published : 2019
DOI: 10.1002/epi4.12349
Open access
Abstract
Objective: To study the effectiveness and tolerability of antiepileptic drugs (AEDs) commonly used in juvenile myoclonic epilepsy (JME). Methods: People with JME were identified from a large database of individuals with epilepsy, which includes detailed retrospective information on AED use. We assessed secular changes in AED use and calculated rates of response (12-month seizure freedom) and adverse drug reactions (ADRs) for the five most common AEDs. Retention was modeled with a Cox proportional hazards model. We compared valproate use between males and females. Results: We included 305 people with 688 AED trials of valproate, lamotrigine, levetiracetam, carbamazepine, and topiramate. Valpr..
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Awarded by Eisai
Funding Acknowledgements
NIHR Health Services and Delivery Research Programme; Royal Melbourne Hospital Foundation; Epilepsy Society; Muir Maxwell Trust; EC grant, Grant/Award Number: 279062; Wellcome Trust; BioCog (EU-funded FP7 research program)