Journal article

A non-dominated sorting Differential Search Algorithm Flux Balance Analysis (ndsDSAFBA) for in silico multiobjective optimization in identifying reactions knockout

Kauthar Mohd Daud, Mohd Saberi Mohamad, Zalmiyah Zakaria, Rohayanti Hassan, Zuraini Ali Shah, Safaai Deris, Zuwairie Ibrahim, Suhaimi Napis, Richard O Sinnott

Computers in Biology and Medicine | Elsevier | Published : 2019

Abstract

Metabolic engineering is defined as improving the cellular activities of an organism by manipulating the metabolic, signal or regulatory network. In silico reaction knockout simulation is one of the techniques applied to analyse the effects of genetic perturbations on metabolite production. Many methods consider growth coupling as the objective function, whereby it searches for mutants that maximise the growth and production rate. However, the final goal is to increase the production rate. Furthermore, they produce one single solution, though in reality, cells do not focus on one objective and they need to consider various different competing objectives. In this work, a method, termed ndsDS..

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