Journal article

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study

Emeline Mullier, Timo Roine, Alessandra Griffa, Lijing Xin, Philipp S Baumann, Paul Klauser, Martine Cleusix, Raoul Jenni, Yasser Aleman-Gomez, Rolf Gruetter, Philippe Conus, Kim Q Do, Patric Hagmann

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | OXFORD UNIV PRESS | Published : 2019

Abstract

BACKGROUND: There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment of oligodendrocytes and parvalbumin interneurons, may underlie brain connectivity alterations in schizophrenia. Accordingly, we previously reported that levels of brain antioxidant glutathione in the medial prefrontal cortex were positively correlated with increased functional connectivity along the cingulum bundle in healthy controls but not in early psychosis patients. In a recent randomized controlled trial, we observed that 6-month supplementation with a glutathione precursor, N-acetyl-cysteine, increased brain glutathione levels and improved symptomatic expr..

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Grants

Awarded by Swiss National Science Foundation


Awarded by National Center of Competence in Research (NCCR) 'SYNAPSY - The Synaptic Bases of Mental Diseases' - Swiss National


Funding Acknowledgements

We thank all patients for their enduring participation. We are grateful for support from the Damm-Etienne Foundation and the Alamaya Foundation. We thank Bioadvantex Pharma, Inc. for providing NAC and placebo. We thank Elsevier Language Editing service for the English language editing.This work was supported by the Swiss National Science Foundation (320030_122419 to P.C. and K.Q.D.; 310030-156874 to P.H.; P2ELP3_172087 to A.G.), National Center of Competence in Research (NCCR) 'SYNAPSY -The Synaptic Bases of Mental Diseases' financed by the Swiss National (no. 51AU40_125759). T.R. received support from Emil Aaltonen (Finland), Technology Industries of Finland Centennial Foundation (Finland), Automation Foundation (Finland), and Oscar Oflunds Stiftelse (Finland). P.S.B. was supported by the Leenaards Foundation.