Journal article

Ligand-Functionalized Poly(ethylene glycol) Particles for Tumor Targeting and Intracellular Uptake.

Jiwei Cui, Karen Alt, Yi Ju, Sylvia T Gunawan, Julia A Braunger, Ting-Yi Wang, Yunlu Dai, Qiong Dai, Joseph J Richardson, Junling Guo, Mattias Björnmalm, Christoph E Hagemeyer, Frank Caruso

Biomacromolecules | American Chemical Society | Published : 2019

Abstract

Drug carriers typically require both stealth and targeting properties to minimize nonspecific interactions with healthy cells and increase specific interaction with diseased cells. Herein, the assembly of targeted poly(ethylene glycol) (PEG) particles functionalized with cyclic peptides containing Arg-Gly-Asp (RGD) (ligand) using a mesoporous silica templating method is reported. The influence of PEG molecular weight, ligand-to-PEG molecule ratio, and particle size on cancer cell targeting to balance stealth and targeting of the engineered PEG particles is investigated. RGD-functionalized PEG particles (PEG-RGD particles) efficiently target U-87 MG cancer cells under static and flow conditio..

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent BioNano Science and Technology


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by National Natural Science Foundation of China


Funding Acknowledgements

This work was conducted and funded by the Australian Research Council Centre of Excellence in Convergent BioNano Science and Technology (project number CE140100036) and the National Health and Medical Research Council (NHMRC) (grant no. 1098867 to K.A. and grant no. 1078118 to C.E.H.). F.C. acknowledges the award of an NHMRC Senior Principal Research Fellowship (GNT1135806). J.C. acknowledges the National Natural Science Foundation of China (21603120, 21872085). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). We thank Mr. Zhiliang Gao at Shandong University for the NMR analysis.