Journal article

Induction and Kinetics of Complement-Fixing Antibodies Against Plasmodium vivax Merozoite Surface Protein 3 alpha and Relationship With Immunoglobulin G Subclasses and Immunoglobulin M

Damian A Oyong, Danny W Wilson, Bridget E Barber, Timothy William, Jianlin Jiang, Mary R Galinski, Freya JI Fowkes, Matthew J Grigg, James G Beeson, Nicholas M Anstey, Michelle J Boyle



BACKGROUND: Complement-fixing antibodies are important mediators of protection against Plasmodium falciparum malaria. However, complement-fixing antibodies remain uncharacterized for Plasmodium vivax malaria. P. vivax merozoite surface protein 3α (PvMSP3α) is a target of acquired immunity and a potential vaccine candidate. METHODS: Plasma from children and adults with P. vivax malaria in Sabah, Malaysia, were collected during acute infection, 7 and 28 days after drug treatment. Complement-fixing antibodies and immunoglobulin M and G (IgM and IgG), targeting 3 distinctive regions of PvMSP3α, were measured by means of enzyme-linked immunosorbent assay. RESULTS: The seroprevalence of complement..

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Awarded by Malaysian Ministry of Health

Awarded by AusAid Asia-Pacific Malaria Elimination Network

Awarded by Australian National Health and Medical Research Council

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by the Malaysian Ministry of Health (grant BP00500420), the AusAid Asia-Pacific Malaria Elimination Network (grant 108-07), the Australian National Health and Medical Research Council (program grants 1037304 and 1092789, project grant 1045156, senior principal research fellowship 1042072 to N. M. A., project grant 1125656 to M. J. B., career development fellowships 1166753 to F. J. I. F. and 1141632 to M. J. B., early career research fellowships 1088738 to B. E. B.., and 1138860 to M. J. G., and senior research fellowship 1077636 to J. G. B.), Charles Darwin University (PhD scholarship to D. A. O.), Menzies School of Health Research (PhD top-up award to D. A. O.), the National Institutes of Health (grants 1R01AI24710 and R01AI0555994 to M. R. G.), and R01AI116472-01 to T. W. the University of Adelaide (Beacon fellowship to D. W. W.), and Channel 7 Children's Research Foundation (grant to D. W. W. and M. J. B.).