Journal article

Investigating causal pathways in severe falciparum malaria: A pooled retrospective analysis of clinical studies

Stije J Leopold, James A Watson, Atthanee Jeeyapant, Julie A Simpson, Nguyen H Phu, Tran T Hien, Nicholas PJ Day, Arjen M Dondorp, Nicholas J White

PLOS MEDICINE | PUBLIC LIBRARY SCIENCE | Published : 2019

Abstract

BACKGROUND: Severe falciparum malaria is a medical emergency characterised by potentially lethal vital organ dysfunction. Patient fatality rates even with parenteral artesunate treatment remain high. Despite considerable research into adjuvant therapies targeting organ and tissue dysfunction, none have shown efficacy apart from renal replacement therapy. Understanding the causal contributions of clinical and laboratory abnormalities to mortality is essential for the design and evaluation of novel therapeutic interventions. METHODS AND FINDINGS: We used a structural model causal inference approach to investigate causal relationships between epidemiological, laboratory, and clinical variables ..

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