Journal article

Impact of Tumor and Immunological Heterogeneity on the Anti-Cancer Immune Response

Carolyn Shembrey, Nicholas D Huntington, Frederic Hollande

CANCERS | MDPI | Published : 2019

Abstract

Metastatic tumors are the primary cause of cancer-related mortality. In recent years, interest in the immunologic control of malignancy has helped establish escape from immunosurveillance as a critical requirement for incipient metastases. Our improved understanding of the immune system's interactions with cancer cells has led to major therapeutic advances but has also unraveled a previously unsuspected level of complexity. This review will discuss the vast spatial and functional heterogeneity in the tumor-infiltrating immune system, with particular focus on natural killer (NK) cells, as well as the impact of tumor cell-specific factors, such as secretome composition, receptor-ligand reperto..

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