Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system
Ludovica Bruno, Vijendra Ramlall, Romain A Studer, Stephan Sauer, David Bradley, Gopuraja Dharmalingam, Thomas Carroll, Mohamed Ghoneim, Michael Chopin, Stephen L Nutt, Sarah Elderkin, David S Rueda, Amanda G Fisher, Trevor Siggers, Pedro Beltrao, Matthias Merkenschlager
Nature Immunology | NATURE PUBLISHING GROUP | Published : 2019
Awarded by Wellcome
Awarded by NIH
We thank A. Warren (University of Cambridge), F. Kondrashov (Institute of Science and Technology Austria), D. Odom (CRUK Cambridge), T. Warnecke, P. Sarkies, S. Santos and B. Lenhard for discussion and advice; N. Speck (University of Pennsylvania) for conditional Runx1 mutants; J. Elliott, B. Patel and T. Adejumo for cell sorting; P. Leung for assistance; D. Djeghloul for help with immunofluorescence; and L. Game and her team for sequencing. This work was funded by the Medical Research Council UK (M.M. and A.G.F.), by Wellcome (grant 099276/Z/12/Z to M. M.) and the NIH (R01A116829 to T. S.).