Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system

Ludovica Bruno; Vijendra Ramlall; Romain A Studer; Stephan Sauer; David Bradley; Gopuraja Dharmalingam; Thomas Carroll; Mohamed Ghoneim; Michael Chopin; Stephen L Nutt; Sarah Elderkin; David S Rueda; Amanda G Fisher; Trevor Siggers; Pedro Beltrao; Matthias Merkenschlager

Journal article

Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system

Ludovica Bruno, Vijendra Ramlall, Romain A Studer, Stephan Sauer, David Bradley, Gopuraja Dharmalingam, Thomas Carroll, Mohamed Ghoneim, Michael Chopin, Stephen L Nutt, Sarah Elderkin, David S Rueda, Amanda G Fisher, Trevor Siggers, Pedro Beltrao, Matthias Merkenschlager

Nature Immunology | NATURE PUBLISHING GROUP | Published : 2019

DOI: 10.1038/s41590-019-0471-5

University of Melbourne Researchers

Stephen Nutt Author Medical Biology (W.E.H.I.)

Michael Chopin Author Medical Biology (W.E.H.I.)

Grants

Awarded by Wellcome

Awarded by NIH

Funding Acknowledgements

We thank A. Warren (University of Cambridge), F. Kondrashov (Institute of Science and Technology Austria), D. Odom (CRUK Cambridge), T. Warnecke, P. Sarkies, S. Santos and B. Lenhard for discussion and advice; N. Speck (University of Pennsylvania) for conditional Runx1 mutants; J. Elliott, B. Patel and T. Adejumo for cell sorting; P. Leung for assistance; D. Djeghloul for help with immunofluorescence; and L. Game and her team for sequencing. This work was funded by the Medical Research Council UK (M.M. and A.G.F.), by Wellcome (grant 099276/Z/12/Z to M. M.) and the NIH (R01A116829 to T. S.).