Journal article

Multistable and multistep dynamics in neutrophil differentiation

Hannah H Chang, Philmo Y Oh, Donald E Ingber, Sui Huang

BMC Cell Biology | Springer Science and Business Media LLC | Published : 2006

DOI: 10.1186/1471-2121-7-11

Abstract

Abstract Background Cell differentiation has long been theorized to represent a switch in a bistable system, and recent experimental work in micro-organisms has revealed bistable dynamics in small gene regulatory circuits. However, the dynamics of mammalian cell differentiation has not been analyzed with respect to bistability. Results Here we studied how HL60 promyelocytic precursor cells transition to the neutrophil cell lineage after stimulation with the differentiation inducer, dimethyl sulfoxide (DMSO). Single cell analysis of the expression kinetics of the differentiation marker CD11b (Mac-1) revealed all-..

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University of Melbourne Researchers