Sex Chromosome Translocations

RJ McKinlay Gardner, David J Amor, RJ McKinlay Gardner (ed.), David J Amor (ed.)

Oxford University Press | Published : 2018


The sex chromosomes (gonosomes) are different, and sex chromosome translocations need to be considered separately from translocations between autosomes. A sex chromosome can engage in translocation with an autosome, with the other sex chromosome, or even with its homolog. The qualities of the sex chromosomes have unique implications in terms of the genetic functioning of gonosome-autosome translocations. This chapter acknowledges the specific peculiarities that the sex chromosomes imply: the X being subject to transcriptional silencing; and the very small Y gene complement being confined largely to sex-determining loci. It reviews translocations between sex chromosomes and autosomes; between..

View full abstract