Journal article

Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores

Peter Goodin, Gemma Lamp, Rishma Vidyasagar, Alan Connelly, Stephen Rose, Bruce C Campbell, Tamara Tse, Henry Ma, David Howells, Graeme J Hankey, Stephen Davis, Geoffrey Donnan, Leeanne M Carey

NEURAL PLASTICITY | HINDAWI LTD | Published : 2019

Abstract

Background: One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in resting-state functional MRI have been investigated to a limited extent. Fluctuations in low frequency signal are reported, but it is unknown if interactions are present between the level of depressive symptom score and intrinsic brain activity in varying brain regions. Objective: To investigate potential interaction effects between whole-brain resting-state activity and depressive symptoms in stroke survivors with low and high levels of depressive symptoms. M..

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Grants

Awarded by James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation-Collaborative Award


Awarded by NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Injury


Awarded by NHMRC Program Grant Saving Brain and Changing Practice in Stroke


Awarded by Australian Research Council Future Fellowship


Funding Acknowledgements

We acknowledge the contribution to this manuscript from the START team of investigators [47]. The authors would like to thank all the participants who gave their time to take part in the study. The authors also wish to acknowledge lead investigators and study coordinators from the START recruiting sites. In particular, we acknowledge and thank those from the START-PrePARE recruiting sites: Austin Hospital (Helen Dewey), Epworth Hospital (Richard Gerraty), Monash Medical Centre (Henry Ma), Royal Melbourne Hospital (Bruce C.V. Campbell), and Western Hospital (Tissa Wijeratne). We acknowledge the financial support for the conduct of the research from the Commonwealth Scientific and Industrial Research Organization (CSIRO) of Australia, Flagship Collaboration Fund through the Preventative Health Flagship, and the support for the analysis, write-up, and researchers from the James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation-Collaborative Award (#220020413), NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Injury (#1077898), NHMRC Program Grant Saving Brain and Changing Practice in Stroke (#1113352), Victorian Government's Operational Infrastructure Support Program, an Australian Research Council Future Fellowship awarded to LMC (#FT0992299), and a La Trobe University Post Graduate Scholarship and Florey student scholarship awarded to TT.