Journal article

Dexmedetomidine reduces norepinephrine requirements and preserves renal oxygenation and function in ovine septic acute kidney injury

Yugeesh R Lankadeva, Shuai Ma, Naoya Iguchi, Roger G Evans, Sally G Hood, David GS Farmer, Simon R Bailey, Rinaldo Bellomo, Clive N May

Kidney International | ELSEVIER SCIENCE INC | Published : 2019

Abstract

Norepinephrine exacerbates renal medullary hypoxia in experimental septic acute kidney injury. Here we examined whether dexmedetomidine, an α2-adrenergic agonist, can restore vasopressor responsiveness, decrease the requirement for norepinephrine and attenuate medullary hypoxia in ovine gram-negative sepsis. Sheep were instrumented with pulmonary and renal artery flow probes, and laser Doppler and oxygen-sensing probes in the renal cortex and medulla. Conscious sheep received an infusion of live Escherichia coli for 30 hours. Eight sheep in each group were randomized to receive norepinephrine, norepinephrine with dexmedetomidine, dexmedetomidine alone or saline vehicle, from 24-30 hours of s..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Future-Leader Postdoctoral Fellowship by the National Heart Foundation of Australia


Funding Acknowledgements

This study was supported by a grant from the National Health and Medical Research Council of Australia (ID APP1050672) and by funding from the Victorian Government Operational Infrastructure Support Grant. YRL was supported by a Future-Leader Postdoctoral Fellowship by the National Heart Foundation of Australia (ID 101853).