Journal article
Age at menopause and lung function: A Mendelian randomisation study
DA van der Plaat, M Pereira, G Pesce, JF Potts, AFS Amaral, SC Dharmage, JM Garcia-Aymerich, JR Thompson, FG Real, DL Jarvis, C Minelli, B Leynaert
European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2019
Open access
Abstract
In observational studies, early menopause is associated with lower forced vital capacity (FVC) and a higher risk of spirometric restriction, but not airflow obstruction. It is, however, unclear if this association is causal. We therefore used a Mendelian randomisation (MR) approach, which is not affected by classical confounding, to assess the effect of age at natural menopause on lung function. We included 94742 naturally post-menopausal women from the UK Biobank and performed MR analyses on the effect of age at menopause on forced expiratory volume in 1 s (FEV1), FVC, FEV1/FVC, spirometric restriction (FVC
Grants
Awarded by Generalitat de Catalunya
Funding Acknowledgements
The current study is part of the Ageing for Lungs in European Cohorts (ALEC) study (www.alecstudy.org), which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement number 633212. This research has been conducted using the UK Biobank Resource under Application Number 19136, and we thank the participants, field workers and data managers for their time and cooperation. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. Funding information for this article has been deposited with the Crossref Funder Registry.