Journal article

Age at menopause and lung function: a Mendelian randomisation study

Diana A van der Plaat, Miguel Pereira, Giancarlo Pesce, James F Potts, Andre FS Amaral, Shyamali C Dharmage, Judith M Garcia-Aymerich, John R Thompson, Francisco Gomez Real, Deborah L Jarvis, Cosetta Minelli, Benedicte Leynaert

European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2019


In observational studies, early menopause is associated with lower forced vital capacity (FVC) and a higher risk of spirometric restriction, but not airflow obstruction. It is, however, unclear if this association is causal. We therefore used a Mendelian randomisation (MR) approach, which is not affected by classical confounding, to assess the effect of age at natural menopause on lung function.We included 94 742 naturally post-menopausal women from the UK Biobank and performed MR analyses on the effect of age at menopause on forced expiratory volume in 1 s (FEV1), FVC, FEV1/FVC, spirometric restriction (FVC<lower limit of normal (LLN)) and airflow obstruction (FEV1/FVC<LLN). We used the inv..

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Awarded by European Union's Horizon 2020 research and innovation programme

Funding Acknowledgements

The current study is part of the Ageing for Lungs in European Cohorts (ALEC) study (, which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement number 633212. This research has been conducted using the UK Biobank Resource under Application Number 19136, and we thank the participants, field workers and data managers for their time and cooperation. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. Funding information for this article has been deposited with the Crossref Funder Registry.