Journal article

White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

Laura S van Velzen, Sinead Kelly, Dmitry Isaev, Andre Aleman, Lyubomir Aftanas, Jochen Bauer, Bernhard T Baune, Ivan Brak, Angela Carballedo, Colm G Connolly, Baptiste Couvy-Duchesne, Kathryn R Cullen, Konstantin Danilenko, Udo Dannlowski, Verena Enneking, Elena Filimonova, Katharina Foerster, Thomas Frodl, Ian H Gotlib, Nynke A Groenewold Show all

MOLECULAR PSYCHIATRY | SPRINGERNATURE | Published : 2020

Abstract

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12-88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and e..

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