Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism
Patricia WM Ho, Audrey S Chan, Nathan J Pavlos, Natalie A Sims, T John Martin
Biochemical Pharmacology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Parathyroid hormone (PTH)-related protein (PTHrP) (gene name Pthlh) was discovered as the factor responsible for the humoral hypercalcemia of malignancy. It shares such sequence similarity with PTH in the amino-terminal region that the two are equally able to act through a single G protein-coupled receptor, PTH1R. A number of biological activities are ascribed to domains of PTHrP beyond the amino-terminal domain. PTH functions as a circulating hormone, but PTHrP is generated locally in many tissues including bone, where it acts as a paracrine factor on osteoblasts and osteocytes. The present study compares how PTH and PTHrP influence cyclic AMP (cAMP) formation through adenylyl cyclase, the ..View full abstract
This work was supported by the National Health and Medical Research Council (Australia) through project grant funding to N.A.S. and T.J.M. and to N.J.P. N.A.S. was supported by an NHMRC Senior Research Fellowship. A.S.C. was supported by the Christine and T.J. Martin Fellowship of the Australian and New Zealand Bone and Mineral Society. St. Vincent's Institute is supported by the Victorian State Government Operational Infrastructure Support scheme.